The main objectives of this research were to investigate the removal of pathogens and heavy metals from wastewater using photogranules and to develop the oxygenic granule process for both central and decentralized systems to treat wastewater. To accomplish our objectives, we convened a research team composed of researchers from Environmental Engineering and Microbiology departments at the University of Massachusetts Amherst. The specific aims of this interdisciplinary research were to: 1) Study the heavy metal removal by the oxygenic photogranule process. 2) Study the efficacy of photogranules in inactivating water-borne pathogenic microorganisms. 3) Investigate continuous wastewater treatment by the oxygenic photogranule process.